I agree I can't stand Tohru from Fruits Basket. She's too happy~ D: Her Japanese and English voice sent chills up my spine.
Heh, I abhor Sasuke from Naruto. Too many fangirls want to 'save' him from his emo-ness way. He brought it all on himself. His thoughts: "ZOMGKILLITACHIANDNARUTO. Oh, and serve Orochimaru.
And lastly, Colette from Tales of Symphonia. Too noble and too much like Tohru. Dx
(x I'm very late, but I saw the Nana (live action) movie pretty recently. The storyline was very good. I'm not sure if it's the same as the manga or anime.